A routine murder investigation pulls a New Orleans detective into a cosmic mystery that forces her to grapple the underlying truths of reality itself. Mike Hoolihan (Patricia Clarkson) is on the case of a famed black hole expert who is found dead of a gunshot wound in her own observatory — and her loopy investigation quickly starts to look as much like a wormhole of experimental physics as a criminal matter.

Clarkson is joined by scene-stealing co-stars including Jacki Weaver and James Caan, in a dreamlike neo-noir which adapts the bleakly comic novel “Night Train” by Martin Amis. No stray evidence or staggeringly cosmic concept is off-limits in a film which breaks all the boundaries of the detective thriller.