Trivia for Like a Boss
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- Salma Hayek previously worked with director Miguel Arteta in Beatriz at Dinner (2017).
- This was the first Paramount Pictures film to use the version of the studio logo with the ViacomCBS byline.
- Marks the second collaboration between Rose Byrne and Jessica St. Clair. The first being Bridesmaids (2011).
- Salma Hayek considered using Botox to help her get into the role of Claire Luna. She finally decided not to because it wouldn't wear off in time for shooting her next film.
- Ryan Hansen and Jimmy O. Yang also played a duo (brothers) in another 2020 film: Fantasy Island.