Desperately Seeking Susan does not move with the self-confidence that its complicated plot requires. But it has its moments, and many of them involve the different kinds of special appeal that Arquette and Madonna are able to generate. They are very particular individuals, and in a dizzying plot they somehow succeed in creating specific, interesting characters.

Roger Ebert

Chicago Sun-Times

Desperately Seeking Susan, based on a good screenplay by a new writer named Leora Barish, is a terrifically genial New York City farce in which the lives of two very different young women become tangled in an Orlon web of lies, half-truths and cross purposes. Full of funny, sharply observed details, reflected in Santo Loquasto's witty production design as well as in all of the dozens of individual performances. The cast is virtually a Players Guide to the variety of performing talent available in New York.

Vincent Canby

The New York Times

A whimsical but optimistic tale of mistaken identity, it starred the Material Girl as the cheekily irresistible Susan, and turned Rosanna Arquette (repressed housewife Roberta) into a star.

William Thomas

Empire